Error in LASA medication administration during anesthesia. Case report

  • Hernán Szmulewicz Department of Anesthesiology, British Hospital of Buenos Aires. Buenos Aires, Argentina. https://orcid.org/0000-0002-3741-3955
  • Charo Martínez Department of Anesthesiology, British Hospital of Buenos Aires. Buenos Aires, Argentina.
  • Guadalupe Saco Department of Anesthesiology, British Hospital of Buenos Aires. Buenos Aires, Argentina.
  • Diego Toscana Department of Anesthesiology, British Hospital of Buenos Aires. Buenos Aires, Argentina.
Keywords: Medication errors, Patient safety, Anesthesia, LASA medications, Safety standards

Abstract

Anesthetic practice involves the use of multiple drugs administered via various routes. Medication administration errors are frequent and represent one of the leading causes of adverse events. The incidence of errors in anesthesia is estimated to range between 0.02% and 1.12%. This case is particularly relevant as it illustrates how the similarity in ampoule appearance can lead to errors, emphasizing the potential risks in anesthetic practice and the need for vigilance. The article discusses the case of a 45-year-old male undergoing elective cholecystectomy. Due to the similarity of ampoule appearances, the anesthesiologist mistakenly administered the wrong medication, fortunately without clinical consequences. Neuromuscular monitoring confirmed the absence of residual effects. Look-Alike Sound-Alike (LASA) medications increase the risk of errors. Factors such as inexperience and time pressure significantly contribute to these events. Implementing preventive measures and strict regulations is essential to mitigate risks. This case highlights the impact of LASA medications in anesthesia and the importance of implementing preventive measures and stringent regulations to minimize such errors. Likewise, it emphasizes the need to adopt enhanced safety protocols and to standardize the ampoules according to international standards. Contributing to improving patient safety during anesthesia requires a systematic approach to identify risks and mitigate the consequences of LASA medications-associated errors.

References

1. Paix AD, Bullock MF, Runciman WB, Williamson JA. Crisis management during anaesthesia: Problems associated with drug administration during anaesthesia. BMJ Qual Saf. 2005;14:e15. https://doi.org/10.1136/qshc.2002.004119

2. Llewellyn RL, Gordon PC, Wheatcroft D, Lines D, Reed A, Butt AD, et al. Drug administration errors: A prospective survey from three South African teaching hospitals. Anaesth Intensive Care. 2009;37(1):93-8. https://doi.org/10.1177/0310057X0903700105

3. Orser BA, Chen RJB, Yee DA. Medication errors in anesthetic practice: A survey of 687 practitioners. Can J Anaesth. 2001;48(2):139-46. https://doi.org/10.1007/BF03019726

4. Abrishami Amir PY. Medication administration errors during general anesthesia – a systematic review of prospective studies. MedRXiv. https://doi.org/10.1101/2023.03.28.23287875ER

5. Gordon PC, Llewellyn RL, James MFM. Drug administration errors by South African anaesthetists – a survey. S Afr Med J. 2006;96(7):630-2. https://doi.org/10.1080/22201173.2006.10872432

6. Murphy BP, Sivaratnam G, Wong J, Chung F, Abrishami A. Medication administration errors during general anesthesia – a systematic review of prospective studies. MedRxiv. 2023;28. https://doi.org/10.1101/2023.03.28.23287875.

7. Bryan R, Aronson JK, Williams A, Jordan S. The problem of look-alike, sound-alike name errors: Drivers and solutions. Br J Clin Pharmacol. 2021;87(2):386-394. https://doi.org/10.1111/bcp.14285.

8. Mendes JR, Lopes MC, Vancini-Campanharo CR, Okuno MF, Batista RE. Types and frequency of errors in the preparation and administration of drugs. Einstein (São Paulo). 2018;16(3):eAO4146. https://doi.org/10.1590/s1679-45082018ao4146

9. Machado Alba JE, Moncada JC, Moreno-Gutiérrez PA. Medication errors in outpatient care in Colombia, 2005-2013. Biomédica: 251-257, 2016 https://doi.org/10.7705/biomedica.v36i2.2693

10. Bryan R, Aronson JK, Williams A, Jordan S. The problem of look-alike, sound-alike name errors: Drivers and solutions. Br J Clin Pharmacol. 2021;87(2):386-394. https://doi.org/10.1111/bcp.14285

11. Ogboli-Nwasor E. Medication errors in anaesthetic practice: A report of two cases and review of the literature. Afr Health Sci. 2013;13(3):845-9. https://doi.org/10.4314/ahs.v13i3.46.

12. Dhawan I, Tewari A, Sehgal S, Chandra Sinha A, et al. Medication errors in anesthesia: Unacceptable or unavoidable? Rev Bras Anestesiol. 2016. https://doi.org/10.1016/j.bjane.2015.09.006.

13. Bryan R, Aronson JK, Williams AJ, Jordan S. A systematic literature review of LASA error interventions. Br J Clin Pharmacol. 2021;87(2):336-351. https://doi.org/10.1111/bcp.14644

14. Schleppers A, Prien T, Van Aken H. Helsinki Declaration on patient safety in anaesthesiology: putting words into practice - experience in Germany. Best Pract Res Clin Anaesthesiol. 2011;25(2):291-304. https://doi.org/10.1016/j.bpa.2011.02.011

15. Administración Nacional de Medicamentos, Alimentos y Tecnología Médica 259 (ANMAT). Normativa Técnica ANMAT-MED-BPF-001-16: Buenas Prácticas 260 de Fabricación para Productos Médicos y de Diagnóstico de Uso In Vitro. 261 [Cited 22 Jan 2024]. Available at: https://www.argentina.gob.ar.

How to Cite
1.
Szmulewicz H, Martínez C, Saco G, Toscana D. Error in LASA medication administration during anesthesia. Case report. Colomb. J. Anesthesiol. [Internet]. 2025 May 20 [cited 2025 Dec. 13];54(1). Available from: https://www.revcolanest.com.co/index.php/rca/article/view/1148

Downloads

Download data is not yet available.
Published
2025-05-20
How to Cite
1.
Szmulewicz H, Martínez C, Saco G, Toscana D. Error in LASA medication administration during anesthesia. Case report. Colomb. J. Anesthesiol. [Internet]. 2025 May 20 [cited 2025 Dec. 13];54(1). Available from: https://www.revcolanest.com.co/index.php/rca/article/view/1148
Section
Case Report / Case Series

Altmetric

Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views
QR Code

Some similar items: