Controlled asystole protocols: a key to more organ donors?

  • Yerlin Andrés Colina Vargas Central Anesthesiology Service, Centro Médico Teknon. Barcelona, Spain; Anesthesiology, Clínica Universitaria Bolivariana, Universidad Pontificia Bolivariana. Medellín, Colombia; Organ, Tissue, and Cell Donation and Transplant Clinic, University of Barcelona. Barcelona, Spain. https://orcid.org/0000-0002-0581-288X
  • David Paredes Zapata Donation and Transplant Coordination Section, Hospital Clinic. Barcelona, Spain; Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Barcelona, Spain. https://orcid.org/0000-0001-9740-4439
  • Juan Ignacio Marín Hepatology and Liver Transplant Unit, Hospital Pablo Tobón Uribe. Medellín, Colombia. https://orcid.org/0000-0001-6954-8910
  • Leonardo Mojica Peñaranda Hepatology and Liver Transplant Unit, Hospital Pablo Tobón Uribe. Medellín, Colombia.
  • Cristian Vera Marín Faculty of Medicine, School of Health Sciences, Universidad Pontificia Bolivariana. Medellín, Colombia. https://orcid.org/0000-0001-6775-151X
  • Carlos Ramírez-Paesano Central Anesthesiology Service, Centro Médico Teknon. Barcelona, Spain. https://orcid.org/0000-0002-1396-8382
Keywords: Transplantation, Tissue and organ procurement, Donor selection, Brain death, Induced cardiac arrest

Abstract

Introduction: Donation after controlled circulatory death (DCD) is organ donation that takes place following diagnosis of death by cardio-respiratory criteria. This diagnosis is certified in patients admitted to the Intensive Care Unit (ICU) following the withdrawal of life-support treatment.

Objectives: To describe the main causes of mortality that make the patient a potential donor under a controlled asystole protocol within the ICU of Hospital Pablo Tobón Uribe in Medellín, Colombia.

Methods: This was an observational, descriptive, retrospective study conducted in adult patients who died during the first quarter of 2024 in any of the ICUs at Hospital Pablo Tobón Uribe in Medellín. Data obtained were analyzed using descriptive statistical methods, and all statistical analyses were performed using Jamovi software.

Results: A total of 103 participants were included, 36 women (35%) and 67 men (65%), with a median age of 61 years (44.5–72). The leading cause of death among participants was septic shock. Seventeen potential donors (16.7%) were identified.

Conclusions: There is significant potential to increase the organ donation rate through the implementation of appropriate controlled asystole protocols.

References

1. Kootstra G, Daemen JH, Oomen AP. Categories of non-heart-beating donors. Transplant Proc. 1995;27(5):2893-4.

2. Bernat JL, D'Alessandro AM, Port FK, Bleck TP, Heard SO, Medina J, et al. Report of a National Conference on Donation after cardiac death. Am J Transplant. 2006;6(2):281-91. https://doi.org/10.1111/j.1600-6143.2005.01194.x.

3. Manara AR, Murphy PG, O'Callaghan G. Donation after circulatory death. Br J Anaesth. 2012;108 Suppl 1:i108-21. https://doi.org/10.1093/bja/aer357.

4. Thuong M, Ruiz A, Evrard P, Kuiper M, Boffa C, Akhtar MZ, et al. New classification of donation after circulatory death donors definitions and terminology. Transpl Int. 2016;29(7):749-59. https://doi.org/10.1111/tri.12776.

5. Shemie SD, Baker AJ, Knoll G, Wall W, Rocker G, Howes D, et al. National recommendations for donation after cardiocirculatory death in Canada: Donation after cardiocirculatory death in Canada. CMAJ. 2006;175(8):S1. https://doi.org/10.1503/cmaj.060895.

6. Reich DJ, Mulligan DC, Abt PL, Pruett TL, Abecassis MM, D'Alessandro A, et al; ASTS Standards on Organ Transplantation Committee. ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation. Am J Transplant. 2009;9(9):2004-11. https://doi.org/10.1111/j.1600-6143.2009.02739.x.

7. Matesanz R. Factors that influence the development of an organ donation program. Transplant Proc. 2004;36(3):739-41. https://doi.org/10.1016/j.transproceed.2004.03.025.

8. Punch JD, Hayes DH, LaPorte FB, McBride V, Seely MS. Organ donation and utilization in the United States, 1996-2005. Am J Transplant. 2007;7(5 Pt 2):1327-38. https://doi.org/10.1111/j.1600-6143.2007.01779.x.

9. Miñambres E, Rubio JJ, Coll E, Domínguez-Gil B. Donation after circulatory death and its expansion in Spain. Curr Opin Organ Transplant. 2018;23(1):120-129. https://doi.org/10.1097/MOT.0000000000000480.

10. Rubio Muñoz JJ. Donación en asistolia. En: Figueroa M, Gamboa G. Tópicos en donación y trasplantes. Sección III. Horizontes futuros de la donación y los trasplantes. Bogotá: Editorial Distribuna; 2024. p. 329-37.

11. Paredes Zapata D. Proyección de la donación en asistolia en Colombia. En: Figueroa M, Gamboa G. Tópicos en donación y trasplantes. Sección III. Horizontes futuros de la donación y los trasplantes. Bogotá: Editorial Distribuna; 2024. p. 339-44

12. Niño Murcia A, Niño Torres L. Futuro de los trasplantes en Colombia. En: Figueroa M, Gamboa G. Tópicos en donación y trasplantes. Sección III. Horizontes futuros de la donación y los trasplantes. Bogotá: Editorial Distribuna; 2024. p. 345-59

13. Domínguez-Gil B, Delmonico FL, Shaheen FA, Matesanz R, O'Connor K, Minina M, et al. The critical pathway for deceased donation: reportable uniformity in the approach to deceased donation. Transpl Int. 2011;24(4):373-8. https://doi.org/10.1111/j.1432-2277.2011.01243.x.

14. Irving MJ, Tong A, Jan S, Cass A, Rose J, Chadban S, et al. Factors that influence the decision to be an organ donor: a systematic review of the qualitative literature. Nephrol Dial Transplant. 2012;27(6):2526-33. https://doi.org/10.1093/ndt/gfr683

15. Louca J, Öchsner M, Shah A, Hoffman J, Vilchez FG, Garrido I, et al; WISPGm; WISPG. The international experience of in-situ recovery of the DCD heart: a multicentre retrospective observational study. EClinicalMedicine. 2023;58:101887. https://doi.org/10.1016/j.eclinm.2023.101887.

16. Louca JO, Manara A, Messer S, Öchsner M, McGiffin D, Austin I, et al. Getting out of the box: the future of the UK donation after circulatory determination of death heart programme. EClinicalMedicine. 2023;66:102320. https://doi.org/10.1016/j.eclinm.2023.102320.

17. Lomero M, Gardiner D, Coll E, Haase-Kromwijk B, Procaccio F, Immer F, et al; European Committee on Organ Transplantation of the Council of Europe (CD-P-TO). Donation after circulatory death today: an updated overview of the European landscape. Transpl Int. 2020;33(1):76-88. https://doi.org/10.1111/tri.13506.

18. Domínguez-Gil B, Ascher N, Capron AM, Gardiner D, Manara AR, Bernat JL, et al. Expanding controlled donation after the circulatory determination of death: statement from an international collaborative. Intensive Care Med. 2021;47(3):265-81. https://doi.org/10.1007/s00134-020-06341-7.

19. Gardiner D, Charlesworth M, Rubino A, Madden S. The rise of organ donation after circulatory death: a narrative review. Anaesthesia. 2020;75(9):1215-22. https://doi.org/10.1111/anae.15100.

20. Lim WH, Domínguez-Gil B. Ethical issues related to donation and transplantation of donation after circulatory determination of death donors. Semin Nephrol. 2022;42(4):151269. https://doi.org/10.1016/j.semnephrol.2022.07.003.

21. McGee A, Gardiner D, Murphy P. Determination of death in donation after circulatory death: an ethical propriety. Curr Opin Organ Transplant. 2018;23(1):114-9. https://doi.org/10.1097/MOT.0000000000000478.

How to Cite
1.
Colina Vargas YA, Paredes Zapata D, Marín JI, Mojica Peñaranda L, Vera Marín C, Ramírez-Paesano C. Controlled asystole protocols: a key to more organ donors?. Colomb. J. Anesthesiol. [Internet]. 2025 May 21 [cited 2025 Jul. 19];. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/1149

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Published
2025-05-21
How to Cite
1.
Colina Vargas YA, Paredes Zapata D, Marín JI, Mojica Peñaranda L, Vera Marín C, Ramírez-Paesano C. Controlled asystole protocols: a key to more organ donors?. Colomb. J. Anesthesiol. [Internet]. 2025 May 21 [cited 2025 Jul. 19];. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/1149
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