Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report

  • Jorge Enrique Machado-Alba Pharmacoepidemiology and Pharmacovigilance Research Group, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia
  • Sivia Fernanda Urbano-Garzón Pharmacoepidemiology and Pharmacovigilance Research Group, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia
  • Yeinson Nabor Yeinson Nabor Pharmacoepidemiology and Pharmacovigilance Research Group, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia
  • Sergio Zuluaica Pharmacoepidemiology Management, Audifarma S.A., Pereira, Colombia
  • Yuly Henao Pharmacoepidemiology Management, Audifarma S.A., Pereira, Colombia
  • Ilsa Yadira Parrado-Fajardo Pharmacoepidemiology Management, Audifarma S.A., Pereira, Colombia
Keywords: Dipyrone, Anaphylaxis, Pharmacovigilance, Drug-related side effects and adverse reactions, Drug hypersensitivity

Abstract

Introduction: The safety of dipyrone has been the object of numerous debates, since severe allergic reactions to it can occur with an estimated incidence of 1 in 5000 parenteral administrations.

Clinical findings: We report the case of one patient who, after an infusion with dipyrone, presented coughing, pharynx itch, dyspnea, generalized cyanosis, and decreased consciousness. The diagnosis of anaphylactic shock without a history of hypersensitivity to the medication was made, and despite treatment with orotracheal intubation, adrenaline, hydrocortisone, sodium chloride, and sodium bicarbonate, it was fatal for the patient.

Conclusion: Cases of severe hypersensitivity without antecedents can be present in patients, which makes it important to recognize this risk in our patients.

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How to Cite
1.
Machado-Alba JE, Urbano-Garzón SF, Yeinson Nabor YN, Zuluaica S, Henao Y, Parrado-Fajardo IY. Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report. Colomb. J. Anesthesiol. [Internet]. 2017Apr.1 [cited 2021May12];45(Supplement):8 - 11. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/434

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Published
2017-04-01
How to Cite
1.
Machado-Alba JE, Urbano-Garzón SF, Yeinson Nabor YN, Zuluaica S, Henao Y, Parrado-Fajardo IY. Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report. Colomb. J. Anesthesiol. [Internet]. 2017Apr.1 [cited 2021May12];45(Supplement):8 - 11. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/434
Section
Case Report / Case Series

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