Pregabalin-induced liver injury - Case report

  • Manuel Quintero-Castellanos a. Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia. b. Unidad Manejo del Dolor, Hospital San Rafael, Tunja, Colombia
Keywords: Low back pain, Pregabalin, Jaundice, Liver failure, Toxicity

Abstract

The first case of idiopathic pregabalin-induced toxicity in Latin America is reported in a patient with radicular pain secondary to lumbar spinal stenosis, who presented with jaundice and elevation of liver enzymes, associated with the use of pregabalin. A diagnosis of drug-induced liver injury was made. Liver function was normalized once the drug was discontinued without any sequelae. It is important to be aware of the potential hepatic toxic effects of pregabalin, despite the fact that the drug shows no evidence of liver metabolism and liver toxicity is very unusual. The liver injury mostly resolves upon pregabalin removal.

References

1. Crespo L, Moreira V, Manzano R, García XA. Colestasis asociada a tratamiento con pregabalina. Med Clin (Barc). 2008;130:157-8.

2. Calzada A, Rubio M, Romero S, Eraíía L. Ictericia asociada al tratamiento con pregabalina. Med Clin (Barc). 2008;131:398-9.

3. Dogan S, Ozberkb S, Yurcia A. Pregabalin-induced hepatotoxicity. Eur J Gastroenterol Hepatol. 2011;23:628.
4. Einarsdottira S, Bjornsson E. Pregabalin as a probable cause of acute liver injury. Eur J Gastroenterol Hepatol. 2008;20:104.

5. Kowar M, Friedrich C, Jacobs AH. Pregabalin as a rare cause of liver disease. Dtsch Med Wochenschr. 2015;140:1759-60.
6. Sendra JM, Junyent TT, Pellicer MJ. Pregabalin-induced hepatotoxicity. Ann Pharmacother. 2011;45:e32.

7. Ben-Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45 Suppl. 6:13-8.

8. Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014;109:950-66.
How to Cite
1.
Quintero-Castellanos M. Pregabalin-induced liver injury - Case report. Colomb. J. Anesthesiol. [Internet]. 2017 Oct. 1 [cited 2024 Mar. 28];45(4):349–352. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/573

Downloads

Download data is not yet available.
Published
2017-10-01
How to Cite
1.
Quintero-Castellanos M. Pregabalin-induced liver injury - Case report. Colomb. J. Anesthesiol. [Internet]. 2017 Oct. 1 [cited 2024 Mar. 28];45(4):349–352. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/573
Section
Case Report / Case Series

Altmetric

Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views
QR Code