Programmed Central Line Change on the Eighth Day Is Better than Being Guided by Signs of Infection for Changing it in Critically-ill Patients
Abstract
Objectives. Comparing the efficacy of a protocol for scheduled central line change 8 days after insertion to local/systemic driven change protocol regarding the prevention of central venous or arterial catheter colonisation and infection.
Design. Prospective, randomised clinical trial.
Patients. All patients admitted to the ICU requiring central venous catheter insertion from August 1st 2008 to October 31st 2009. Patients were randomly assigned to one of two groups according to timing of central line exchange. In one group, venous catheter was removed by day 8, and in the other group, it was removed guided by local or systemic signs of infection.
Measurements and Main Results. Catheter distal tips were quantitatively cultured in all patients. Significant catheter colonisation rate (i.e. > or = 103 colony-forming units [cfu]/mL by quantitative culture) and catheter-related sepsis (as defined by sepsis abating following catheter removal per 1,000 catheter-days) were significantly lower in the 8th day removal group (12 vs. 31 [0.4 relative risk; 0.1 to 0.9 95 % confidence interval; p < 0.1] and 6 vs. 16 [0.4 relative risk; 0.1 to 0.97 95 % confidence interval; p=0.05], respectively). Central venous catheter colonisation and central venous catheter-related sepsis rate per 1,000 catheter-days were also significantly lower in the 8th day removal group (8 vs. 31 [0.3 relative risk; 0.1 to 0.9 95 % confidence interval; p = 0.03] and 5 vs. 19 [0.3 relative risk; 0.1 to 0.9 95 % confidence interval; p = 0.02], respectively).
Conclusions. The 8th day catheter removal strategy was more effective than catheter removal strategy guided by signs of infection in terms of colonisation and catheter-related sepsis.
References
2. Raad II, Costerton W. Ultrastructural analysis of indwelling catheters: A quantitative relationship between luminal colonization and duration of placement. J Infect. Dis. 1993. 168:400-407.
3. Pronovost PJ. Interventions to decrease catheter-related bloodstream infections in the ICU: The Keystone Intensive Care Unit Project. Infect. Control 2008; 36:S71 e1 S171 e5.
4. Pronovost PJ, Weast B, Rosenstein B et al. Implementing and validating a comprehensive unit based safety program. J Patient Saf. 2005;1:33-40.
5. Berenholta SM, Pronovost PJ. Lipsett PA, Hobson D, Earsing K, Farley JE, et al. Eliminating catheter-related bloodstream infections in the intensive care unit. Crit. Care. Med. 2004;32:2014-2020.
6. O´Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. MMWR. Recomm. Rep. 2002;51(RR10):1-29.
7. Brun-Buisson C, Abrouk F, Legrand P, Diagnosis of central venous catheter-related sepsis: Critical level of quantitative tip cultures. Arch. Intern. Med. 1987.147:873-877.
8. Henderson DK. Bactermia due to percutaneous intravascular devices. In Principles and Practice of Infectious Diseases. Mandell GL, Douglas RG, Bennett JE (Eds.). New York. John Willey and Sons. 1990. pp 2189-2199.
9. Cobb DK, High KP, Sawyer RG, et al: A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med 1992; 327:1062-1068.
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