@article{Trujillo-Zea_Aristizábal-Henao_Fonseca-Ruiz_2015, title={Lactated Ringer’s vs. normal saline solution for renal transplantation: Systematic review and meta-analysis}, volume={43}, url={https://www.revcolanest.com.co/index.php/rca/article/view/156}, abstractNote={<p><em>Background: </em>The administration of potassium solutions may result in hyperpotassemia during surgery; normal saline solution (NSS) traditionally used in renal transplant may cause hyperchloremic acidosis.</p> <p><em>Objective: </em>To compare the safety of Lactated Ringer's (LR) against NSS in renal transplantation.</p> <p><em>Search strategy: A </em>systematic review was completed on Central Cochrane Registry - controlled trials, Medline, Lilacs, EBSCO and Embase, accessing review articles and contacting expert clinicians. There was no language restriction.</p> <p><em>Selection criteria:</em> Randomized controlled trials on adult patients undergoing renal transplantation.</p> <p><em>Data collection and analysis:</em> Independent trial selection, quality assessment and data extraction were performed. The mean differentials were estimated with a 95% confidence interval (95% CI). Heterogeneity was evaluated with statistic I-square(I<sup>2</sup>) and the fixed and random effect models were used.</p> <p><em>Results:</em> Four trials with a total of 237 patients were included. At the end of surgery, the potassium differential was non-significant (means difference (MD: -0.26 mEq/L; CI 95%: -0.58 to 0.05 <em>p </em>= 0.10; I<sup>2</sup> = 75%); the pH was lower in the NSS group (MD: 0.06; CI 95%: 0.05-0.08; <em>p </em>< 0.001; I<sup>2</sup> = 17%). No difference in Creatinine was identified on the third postoperative day (MD: -0.05; CI 95%: -0.59 to 0.48; <em>p </em>= 0.85; I<sup>2</sup> = 0%).</p> <p><em>Condusions:</em> The use of RL vs. NSS during the renal transplantation perioperative period results in lower potassium and chloride levels and a higher pH, with no significant Creatinine changes.</p>}, number={3}, journal={Colombian Journal of Anesthesiology}, author={Trujillo-Zea, Jorge Alejandro and Aristizábal-Henao, Natalia and Fonseca-Ruiz, Nelson}, year={2015}, month={Jul.}, pages={194–203} }