TY - JOUR AU - González Cárdenas, V.H. PY - 2012/04/01 Y2 - 2024/03/28 TI - Neonatal Respiratory Depression and Intrathecal Fentanyl JF - Colombian Journal of Anesthesiology JA - Colomb. J. Anesthesiol. VL - 40 IS - 2 SE - Original DO - UR - https://www.revcolanest.com.co/index.php/rca/article/view/817 SP - 100-105 AB - <p><strong><em>Objective</em>:</strong>&nbsp;To establish the prevalence of neonatal respiratory depression in patients exposed to intrathecal fentanyl during Cesarean section.</p><p><strong><em>Methods</em>:&nbsp;</strong>Cross-sectional Analytical Observational Retrospective Study conducted at the Mother and Child Clinic of the Saludcoop Corporation in patients undergoing C-section who received intrathecal fentanyl for regional anesthesia in 2007 and 2008. Primary endpoints: low APGAR score (APGAR&lt;7) and severe APGAR (APGAR&lt;4).</p><p><strong><em>Results</em>:</strong>&nbsp;2165 records of C-sections and intrathecal fentanyl with a mean dose of 19.21mcg (SD=0.206mcg). Prevalence of low APGAR at 1.5 and 10 minutes was 1.77% (SD=0.63%), 0.11% (SD 0.163%), and 0%, respectively. The latter two values were different from the 1-minute value (ANOVA Scheffé Test, p=0.031) and there was no difference between them (minutes 5 and 10) (ANOVA p=0.861). Severely diminished APGAR results were, 0.059% (SD 0.058) 1 minute after birth and 0% at 5 and 10 minutes. There were no statistically significant differences between the three severely diminished values (ANOVA p=0.861).</p><p><strong><em>Conclusions</em>:&nbsp;</strong>The prevalence of respiratory depression measured with the APGAR test at birth is low; severely compromised APGAR shows a trend towards 0 in the different minutes of assessment. However, the reliability of the diagnostic tool (APGAR) is questionable, considering discrepancies when the analysis is done with a far more sensitive diagnostic tool (Silverman test).</p><p>The importance of this study relates only to the assessment of prevalence and its use as a source of a research hypothesis, and not as an association or prediction study.</p> ER -