No es tan sencillo como "Te pondré a dormir": una perspectiva neurobiológica sobre la sedación

1. Ju YE, Lucey BP, Holtzman DM. Sleep and Alzheimer disease pathology a bidirectional relationship. Nat Rev Neurol. 2014:115-9.
2. KangJ-E, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, et al. Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009;326:1005-7.
3. Huang Y, Potter R, Sigurdson W, Santacruz A, Shih S, Ju YE, et al. Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system. Arch Neurol. 2012;69:51-8.
4. Sundman MH, Hall EE, Chen NK. Examining the relationship between head trauma and neurodegenerative disease: a review of epidemiology, pathology and neuroimaging techniques. J Alzheimers Dis Parkinsonism. 2014;4:131.
5. Le Freche H, Brouillette J, Fernandez-Gomez FJ, Patin P, Caillierez R, Zommer N, et al. Tau phosphorylation and sevofluraneanesthesia: an association to postoperative cognitive impairment. Anesthesiology. 2012;116:779-87.
6. Tan W, Cao X, Wang J, Lv H, Wu B, Ma H. Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats. Eur J Anaesthesiol. 2010;27:835-11.
7. Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, et al. Propofol directly increases tau phosphorylation. PLoS ONE. 2011;6:e16648.
8. Cepeda-Prado E, Popp S, Khan U, Stefanov D, Rodríguez J, Menalled LB, et al. R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures. J Neurosci. 2012;32:6456-67.
9. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373-7.
10. Llinas RJ. Of self and self awareness: the basic neuronal circuit in human consciousness and the generation of self. J Conscious Stud. 2008;15:64-74.
11. Plum F, Schiff N, Ribary U, Llinas R. Coordinated expression in chronically unconscious persons. Philos Trans R Soc Lond B: Biol Sci. 1998;353:1929-33.