Haloperidol as prophylactic treatment for postoperative nausea and vomiting: Systematic literature review
Keywords:
Haloperidol, Vomiting, Nausea, Clinical trials.
Abstract
Introduction: The effectiveness of haloperidol for the prophylaxis of postoperative nausea and vomiting (PONV) has been proven in prior trials summarized by Buttner in 2004. New evidence has surfaced since then. Our objective is thus to update the current knowledge on the topic. A systematic review and a meta-analysis were performed, in order to determine the effectiveness and safety of the use of haloperidol as prophylaxis for PONV.
Methodology: The systematic search, the selection of relevant articles, the extraction of data, the critical analysis of the primary studies, the comparisons and analyses were all based on the recommendations of the Cochrane Collaboration and using RevMan5 software.
Results: Ten controlled clinical trials published between 1962 and 2010, that included 2,711 patients, met the selection criteria. As compared against droperidol (RR: 0.97; 95% CI: 0.52-1.79) and against ondansetron (RR: 1.24; 95% CI: 0.66-2.35), no differences were found in terms of effectiveness after 24 hours. A protective effect against PONV associated with the use of haloperidol at varying doses, routes of administration and timing of administration was observed as compared with placebo. No significant increases in adverse events have been reported.
Discussion: This systematic review supports the effectiveness of haloperidol as prophylactic treatment of PONV. No statistically significant differences were found as compared against ondansetron or droperidol.
Conclusions: Haloperidol is an effective prophylactic drug for PONV.
References
1. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment and prevention. Anesthesiology. 1992;77:162-84.
2. Kapur PA. Editorial: The big «little problem». Anesth Analg. 1991;73:243-5.
3. Kortilla K. The study of postoperative nausea and vomiting. Br J Anaesth. 1992;69 Suppl 1:20S-3S.
4. Rüsch D, Eberhart L, Biedler A, Dethling J, Apfel CC. Prospective application of a simplified risk score to prevent postoperative nausea and vomiting. Can J Anaesth. 2005;52:478-84.
5. Kenny G. Risk factors for postoperative nausea and vomiting. Anaesthesia. 1994;49 Suppl:6-10.
6. Rashiq S, Bray P. Relative value to surgical patients and anesthesia providers of selected anesthesia related outcomes. BMC Med Inform Decis Mak. 2003 Feb 13;3:3. Epub 2003 Feb 13.
7. Büttner M, Walder B, von Elm E, Tramèr MR. Is low-dose haloperidol a useful antiemetic? Anesthesiology. 2004;101:1454-63.
8. White PF. Droperidol a cost effective antiemetic for over thirty years. Anesth Analg. 2002;95:789-90.
9. Habib AS, Gan TJ. Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases. Anest Analg. 2003;96:1377-9.
10. Sharna ND, Rosman HS, Padhi ID, Tisdale JE. Torsades de Pointes associated with intravenous haloperidol in critically ill patients. Am J Cardiol. 1998;81:238-44.
11. Loeser EA, Bennett G, Stanley TH, Machin R. Comparison of Droperidol, Haloperidol And Prochlorperazine As Postoperative Anti-emetics. Canad Anaesth Soc J. 1979;26:125-7.
12. Yang YL, Lai HY, Wang JJ. The timing of haloperidol administration does not affect its prophylactic antiemetic efficacy. Can J Anesth. 2008;55:270-5, 5.
13. Chaparro LE, Gallo T, Gonzalez NJ. Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. European Journal of Anaesthesiology. 2010;27:192-5.
14. Tsai Y-Ch. Haloperidol, droperidol, or neither for PONV prophylaxis. Acta Anaesthesiol Taiwan. 2009;47:1-2.
15. Carlisle JB, Stevenson CA. Fármacos para la prevención de náuseas y vómitos postoperatorios (Cochrane Review). La Biblioteca Cochrane Plus. 2008.
16. Apfel CC, Kranke P, Eberhart LHJ, Roos A, Roewer N. Comparison of predictive models for postoperative nausea and vomiting. Br J Anaesth. 2002;88:234-40.
17. Gan T, Sloan F, Dear G, de L, El-Moalem HE, Lubarsky DA. How much are patients willing to pay to avoid postoperative nausea and vomiting? Anesth Analg. 2001;92:393-400.
18. Eberhart LH, Mauch M, Morin AM, Wulf H, Geldner G. Impact of a multimodal anti-emetic prophylaxis on patient satisfaction in high-risk patients for postoperative nausea and vomiting. Anaesthesia. 2002;57:1022-7.
19. Engoren M, Steffel C. Patient perception of monetary value to avoiding unpleasant side effects of anesthesia and surgery. J Clin Anesth. 2000;12:388-91.
20. Forthey JT, Gan TJ, Graczyk S, Wetchler B, Melson T, Khalil S, et al. A Comparison of efficacy, safety and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procidures. Anesth Analg. 1998;86:731-8.
21. Van den Bosch JE, Kalkman CJ, Vergouwe Y, Van Klei WA, Bonsel GJ, Grobbee DE, et al. Assessing the applicability of scoring systems for predicting postoperative nausea and vomiting. Anaesthesia. 2005;60:323-31.
22. Supplementary data. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Disponible en: http://www.hcuge.ch/anesthesie/data.htm consultado 12 Dic 2010 .
23. Aouad MT, Siddik-Sayyid SM, Taha SK, Azar MS, Nasr VG, Hakki MA, et al. Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. Eur J Anaesthesiol. 2007;24:171-8.
24. Chu CC, Shieh JP, Tzeng JI, Chen JY, Lee Y, Ho ST, et al. The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. Anesth Analg. 2008;106:1402-6.
25. Feng PH, Chu KS, Lu IC, Shieh JP, Tzeng JI, Ho ST, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan. 2009;47:3-9.
26. Lee Y,Wang PK, Lai HY, Yang YL, Chu CC,Wang JJ. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth. 2007;54:349-54.
27. Parlow JL, Costache I, Avery N, Turner K. Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine. Anesth Analg. 2004;98:1072-6.
28. Wang MD. Perioperative haloperidol usage for delirium management. J Am Geriatr Soc. 2006;54:860-1, author reply 861-863.
29. Wang TF, Liu YH, Chu CC, Shieh JP, Tzeng JI, Wang JJ. Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery. Acta Anaesthesiol Scand. 2008;52:280-4.
30. Yang YL, Lai HY, Wang JJ, Wang PK, Chen TY, Chu CC, et al. The timing of haloperidol administration does not affect its prophylactic antiemetic efficacy. Can J Anaesth. 2008;55:270-5.
31. Barton MD, Libonati M, Cohen PJ. The use of haloperidol for treatment of postoperative nausea and vomiting-a double-blind placebo-controlled trial. Anesthesiology. 1975;42:508-12.
32. Buttner M, Walder B, von Elm E, Tramer MR. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Anesthesiology. 2004;101:1454-63.
33. Dagtekin O, Wiese P, Wolter K, Hermann MM, Pietruck C, Kampe S. Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. Pharmacology. 2009;83:205-10.
34. Dyrberg V. Haloperidol (Serenase) in the prevention of postoperative nausea and vomiting. Acta Anaesthesiol Scand. 1962;6:37-47.
35. Eberhart LH, Mauch M, Morin AM, Wulf H, Geldner G. Impact of a multimodal anti-emetic prophylaxis on patient satisfaction in high-risk patients for postoperative nausea and vomiting. Anaesthesia. 2002;57:1022-7.
36. Grecu L, Bittner EA, Kher J, Smith SE, Rosow CE. Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1410-3.
37. Habib AS, Gan TJ. Haloperidol for postoperative nausea and vomiting: are we reinventing the wheel? Anesth Analg. 2008;106:1343-5.
38. Jokela RM, Cakmakkaya OS, Danzeisen O, Korttila KT, Kranke P, Malhotra A, et al. Ondansetron has similar clinical efficacy against both nausea and vomiting. Anaesthesia. 2009;64:147-51.
39. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. Int J Surg. 2012;10:28-55.
40. Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1407-9.
2. Kapur PA. Editorial: The big «little problem». Anesth Analg. 1991;73:243-5.
3. Kortilla K. The study of postoperative nausea and vomiting. Br J Anaesth. 1992;69 Suppl 1:20S-3S.
4. Rüsch D, Eberhart L, Biedler A, Dethling J, Apfel CC. Prospective application of a simplified risk score to prevent postoperative nausea and vomiting. Can J Anaesth. 2005;52:478-84.
5. Kenny G. Risk factors for postoperative nausea and vomiting. Anaesthesia. 1994;49 Suppl:6-10.
6. Rashiq S, Bray P. Relative value to surgical patients and anesthesia providers of selected anesthesia related outcomes. BMC Med Inform Decis Mak. 2003 Feb 13;3:3. Epub 2003 Feb 13.
7. Büttner M, Walder B, von Elm E, Tramèr MR. Is low-dose haloperidol a useful antiemetic? Anesthesiology. 2004;101:1454-63.
8. White PF. Droperidol a cost effective antiemetic for over thirty years. Anesth Analg. 2002;95:789-90.
9. Habib AS, Gan TJ. Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases. Anest Analg. 2003;96:1377-9.
10. Sharna ND, Rosman HS, Padhi ID, Tisdale JE. Torsades de Pointes associated with intravenous haloperidol in critically ill patients. Am J Cardiol. 1998;81:238-44.
11. Loeser EA, Bennett G, Stanley TH, Machin R. Comparison of Droperidol, Haloperidol And Prochlorperazine As Postoperative Anti-emetics. Canad Anaesth Soc J. 1979;26:125-7.
12. Yang YL, Lai HY, Wang JJ. The timing of haloperidol administration does not affect its prophylactic antiemetic efficacy. Can J Anesth. 2008;55:270-5, 5.
13. Chaparro LE, Gallo T, Gonzalez NJ. Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. European Journal of Anaesthesiology. 2010;27:192-5.
14. Tsai Y-Ch. Haloperidol, droperidol, or neither for PONV prophylaxis. Acta Anaesthesiol Taiwan. 2009;47:1-2.
15. Carlisle JB, Stevenson CA. Fármacos para la prevención de náuseas y vómitos postoperatorios (Cochrane Review). La Biblioteca Cochrane Plus. 2008.
16. Apfel CC, Kranke P, Eberhart LHJ, Roos A, Roewer N. Comparison of predictive models for postoperative nausea and vomiting. Br J Anaesth. 2002;88:234-40.
17. Gan T, Sloan F, Dear G, de L, El-Moalem HE, Lubarsky DA. How much are patients willing to pay to avoid postoperative nausea and vomiting? Anesth Analg. 2001;92:393-400.
18. Eberhart LH, Mauch M, Morin AM, Wulf H, Geldner G. Impact of a multimodal anti-emetic prophylaxis on patient satisfaction in high-risk patients for postoperative nausea and vomiting. Anaesthesia. 2002;57:1022-7.
19. Engoren M, Steffel C. Patient perception of monetary value to avoiding unpleasant side effects of anesthesia and surgery. J Clin Anesth. 2000;12:388-91.
20. Forthey JT, Gan TJ, Graczyk S, Wetchler B, Melson T, Khalil S, et al. A Comparison of efficacy, safety and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procidures. Anesth Analg. 1998;86:731-8.
21. Van den Bosch JE, Kalkman CJ, Vergouwe Y, Van Klei WA, Bonsel GJ, Grobbee DE, et al. Assessing the applicability of scoring systems for predicting postoperative nausea and vomiting. Anaesthesia. 2005;60:323-31.
22. Supplementary data. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Disponible en: http://www.hcuge.ch/anesthesie/data.htm consultado 12 Dic 2010 .
23. Aouad MT, Siddik-Sayyid SM, Taha SK, Azar MS, Nasr VG, Hakki MA, et al. Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. Eur J Anaesthesiol. 2007;24:171-8.
24. Chu CC, Shieh JP, Tzeng JI, Chen JY, Lee Y, Ho ST, et al. The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. Anesth Analg. 2008;106:1402-6.
25. Feng PH, Chu KS, Lu IC, Shieh JP, Tzeng JI, Ho ST, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan. 2009;47:3-9.
26. Lee Y,Wang PK, Lai HY, Yang YL, Chu CC,Wang JJ. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth. 2007;54:349-54.
27. Parlow JL, Costache I, Avery N, Turner K. Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine. Anesth Analg. 2004;98:1072-6.
28. Wang MD. Perioperative haloperidol usage for delirium management. J Am Geriatr Soc. 2006;54:860-1, author reply 861-863.
29. Wang TF, Liu YH, Chu CC, Shieh JP, Tzeng JI, Wang JJ. Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery. Acta Anaesthesiol Scand. 2008;52:280-4.
30. Yang YL, Lai HY, Wang JJ, Wang PK, Chen TY, Chu CC, et al. The timing of haloperidol administration does not affect its prophylactic antiemetic efficacy. Can J Anaesth. 2008;55:270-5.
31. Barton MD, Libonati M, Cohen PJ. The use of haloperidol for treatment of postoperative nausea and vomiting-a double-blind placebo-controlled trial. Anesthesiology. 1975;42:508-12.
32. Buttner M, Walder B, von Elm E, Tramer MR. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Anesthesiology. 2004;101:1454-63.
33. Dagtekin O, Wiese P, Wolter K, Hermann MM, Pietruck C, Kampe S. Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery. Pharmacology. 2009;83:205-10.
34. Dyrberg V. Haloperidol (Serenase) in the prevention of postoperative nausea and vomiting. Acta Anaesthesiol Scand. 1962;6:37-47.
35. Eberhart LH, Mauch M, Morin AM, Wulf H, Geldner G. Impact of a multimodal anti-emetic prophylaxis on patient satisfaction in high-risk patients for postoperative nausea and vomiting. Anaesthesia. 2002;57:1022-7.
36. Grecu L, Bittner EA, Kher J, Smith SE, Rosow CE. Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1410-3.
37. Habib AS, Gan TJ. Haloperidol for postoperative nausea and vomiting: are we reinventing the wheel? Anesth Analg. 2008;106:1343-5.
38. Jokela RM, Cakmakkaya OS, Danzeisen O, Korttila KT, Kranke P, Malhotra A, et al. Ondansetron has similar clinical efficacy against both nausea and vomiting. Anaesthesia. 2009;64:147-51.
39. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. Int J Surg. 2012;10:28-55.
40. Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1407-9.
How to Cite
1.
Chaparro C, Moreno D, Ramírez V, Fajardo A, Gonzalez D, Sanin A, et al. Haloperidol as prophylactic treatment for postoperative nausea and vomiting: Systematic literature review. Colomb. J. Anesthesiol. [Internet]. 2013 Jan. 1 [cited 2024 May 5];41(1):34-43. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/633
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2013-01-01
How to Cite
1.
Chaparro C, Moreno D, Ramírez V, Fajardo A, Gonzalez D, Sanin A, et al. Haloperidol as prophylactic treatment for postoperative nausea and vomiting: Systematic literature review. Colomb. J. Anesthesiol. [Internet]. 2013 Jan. 1 [cited 2024 May 5];41(1):34-43. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/633
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Systematic review
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