Management of perioperative bleeding in children. Step by step review
Keywords:
Bleeding, Blood transfusion, Hypovolemia, Child.
Abstract
Introduction: Appropriate replacement of blood losses is essential to reduce morbidity and mortality in the surgical pediatric patient.
Objective: Non-systematic reviewof the literature on the management of perioperative bleeding in children.
Methodology: A systematic literature review using Pubmed, Medline, Ovid and Cochrane databases was completed on articles describing the management of perioperative bleeding in children.
Results: Readiness is a must in situations where massive bleeding is expected. You should be knowledgeable about the indications for transfusion therapy, the prevention and management of complications of massive transfusion and the use of perioperative hemostatic agents when indicated.
References
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2. Barcelona S, Cote CH, Thompson A. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part II: Transfusion therapy, special considerations, and reduction of allogenic blood transfusions. Paediatr Anaesth. 2005;15:814-30.
3. Istaphanous G, Wheeler D, Lisco S, Shander A. Red blood cell transfusion in critically ill children: A narrative review. Pediatr Crit Care Med. 2011;12:174-83.
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8. Verma A, Hemlata D. Blood component therapy. Indian J Pediatr. 2008;75:717-22.
9. Haetrey R. Transfusion principles in children. Anaesth Intensive Care. 2009;10:71-5.
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13. Poterjoy B, Josephson C. Platelets frozen plasma, and cryoprecipitate: What is the clinical evidence for their use in the neonatal intensive care unit? Semin Perinatol. 2009;33:66-74.
14. Chang TT. Transfusion therapy in critically ill children. Pediatrics and Neonatology. 2008;49:5-12.
15. Roback J, Cadwell S, Carson J, Devenport R. Evidence-based practice guidelines for plasma transfusion. Transfusion. 2010;50:1227-39.
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17. Sorensen B, Bevan D. A critical evaluation of cryoprecipitate for replacement of fibrinogen. Br J Haematol. 2010;149:834-43.
18. Callun J, Karkouti K, Lin Y. Cryoprecipitate: The current state of knowledge. Transfus Med Rev. 2009;23: 177-88.
19. Rossaint R, Bouillon B, Cerny V, Coats T. Management of bleeding following major trauma an updated European guideline. Critical Care. 2010;14:R52.
20. Dressler A, Finck C, Carrol C, Bonnani C, Spinella P. Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a child. J Pediatr Surg. 2010;45:1530-3.
21. Dehmer J, Adamson W. Massive transfusion and blood product use in the pediatric trauma patient. Semin Pediatr Surg. 2010;19:286-91.
22. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010;137:209-20.
23. Sihler K, Napolitano L. Massive transfusion new insights. Chest. 2009;136:1654-67.
24. Downes K, Sarode R. Massive blood loss transfusion. Indian J Pediatr. 2001;68:145-9.
25. Barcelona S, Cote CH, Thompson A. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part I: hematologic and physiologic differences from adults; metabolic and infectious risks. Paediatr Anaesth. 2005;15:716-26.
26. Schouten E, van de Pol A, Turnel M, Jansen N. The effect of aprotinin, tranexamic acid, and aminocaproic acid blood loss and use of blood products in major pediatric surgery: A meta-analysis. Pediatr Crit Care Med. 2009;10:182-90.
27. Goobie S, Meier P, Pereira L, McGowan F, Prescilla R, Scharp L, et al. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011;114:862-71.
28. Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, et al. Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology. 2011;114:856-61.
29. Tzortzopolou A, Cepeda MS, Schuman R, Carr DB. Antifibrinolitic agents for reducing blood loss in scoliosis surgery in children (review). The Cochrane database of systematic review. 2009;Issue 1.
30. Grant JA, Howard J, Luntley J, Harder J, Aleissa S, Parsons D. Perioperative blood transfusion requirements in pediatric scoliosis surgery: the efficacy of tranexamic acid. J Pediatr Orthop. 2009;29:300-4.
31. Franchini M. The use of desmopressin as a hemostatic agent: a concise review. Am J Hematol. 2007;82:731-5.
32. Benito H, Hernandez R, Fernandez Reyes J. Management of perioperative bleeding in renal patients. Nefrologia. 2008;28:593-6.
33. Levy J, Kenishi A, Tanaka K. Prohemostatic agents to prevent perioperative blood loss. Semin Thromb Hemost. 2008;34:439-44.
34. Ozgonenel B, Rajpurkar M, Lussher J. How do you treat bleeding disorders with desmopressin? Postgrad Med J. 2007;83:159-63.
35. Franchini M, Lippi G. Recombinant activated factor VII: Mechanisms of action and current indications. Semin Thromb Hemost. 2010;36.
36. Logan A, Lawrence T, Goodnough T. Recombinant factor VIIa: An assessment of evidence regarding its efficacy and safety in the off-label setting. Hematology. 2010:153-9.
37. Persson E, Bolt G, Steentrup T, Ezban M. Recombinant coagulation factor VIIa - from molecular to clinical aspects of a versatile haemostatic agent. Thromb Res. 2010;125: 483-9.
38. Vincent J, Rossaint R, Riou B, Ozier Y, Zideman D. Recommendations on the use of recombinant a potential l universal hemostatic agent. Expert Opin Biol Ther. 2009;9:1325-33.
39. Alten J, Benner K, Green K, Toole B, Tofil N. Pediatric off label use of recombinant factor VIIa. Pediatrics. 2009;123:1066-72.
40. Hong I, Stachnik J. Unlabeled uses of factor VIIa (recombinant) in pediatric patients. Am J Health Syst Pharm. 2010;67:1909-19.
41. Witmer CM, Huang YS, Lynch K, Raffini LJ, Shah S. Off-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study. J Pediatr. 2011;158:820-5.
42. Levi M, Levy J, Friis H. Safety of recombinant activated factor VII in randomized clinical trials. N England J Med. 2010;363:19.
43. Lin Y, Stanworth S, Birchall J, Doree C. Use of recombinant factor VIIa for the prevention and treatment of bleeding in patients without hemophilia: a systematic review and meta-analysis. CMAJ. 2011;183:E9-19.
44. Fenger-Eriksen C, Ingersley J, Sorensen B. Fibrinogen concentrate - a potential universal hemostatic agent. Expert Opin Biol Ther. 2009;9:1325-33.
45. Franchinni M, Lippi G. Prothrombin complex concentrates: an update. Blood Transfus. 2010;8:149-54.
46. Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the use of antithrombin concentrates and prothrombin complex concentrates. Blood Transfus. 2009;7:325-34.
47. Perry D, Fitzmaurice D, Kitchen S, Mackie I. Point-of-care testing in haemostasis. Br J Haematol. 2010;150:501-14.
48. Sibylle A, Kozek-Langenecker. Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol. 2010;24:27-40.
49. Ganter M, Hofer C. Coagulation monitoring: Current techniques and clinical use of viscoelastic point of care coagulation devices. Anesth Analg. 2008;106:1366-75.
50. Lavoie J. Blood transfusion risks and alternative strategies in pediatric patients. Pediatric Anesthesia. 2011;21:14-24.
51. Verma S, Eisses M, Richards M. Blood conservation strategies in pediatric patient. Anesthesiol Clin. 2009;27:337-55.
52. Griffee M, DeLoughery T, Thorborg T. Coagulation management in massive bleeding. Current Opinion in Anaesthesiology. 2010;23:263-8.
2. Barcelona S, Cote CH, Thompson A. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part II: Transfusion therapy, special considerations, and reduction of allogenic blood transfusions. Paediatr Anaesth. 2005;15:814-30.
3. Istaphanous G, Wheeler D, Lisco S, Shander A. Red blood cell transfusion in critically ill children: A narrative review. Pediatr Crit Care Med. 2011;12:174-83.
4. Casino R, Luban N. Blood component therapy. Pediatric Clin North Am. 2008;55:421-45.
5. Morley S. Red blood cell transfusions in acute paediatrics. Arch Dis Child Educ Pract Ed. 2009;94:65-73.
6. Uppal P, Lodha R, Kabra S. Transfusion of blood and components in critically ill children. Indian J Pediatr. 2010;77:1424-8.
7. Chang T. Transfusion therapy in critically children. Pediatr Neon. 2008;49:5-12.
8. Verma A, Hemlata D. Blood component therapy. Indian J Pediatr. 2008;75:717-22.
9. Haetrey R. Transfusion principles in children. Anaesth Intensive Care. 2009;10:71-5.
10. Belli M. Red blood cell transfusion. Pediatr Rev. 2007;28:299-304.
11. Todd A. Transfusion of blood product in paediatrics. Anaesth Intensive Care. 2006;7:9-11.
12. Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the transfusion of plasma and platelets. Italian Society of Transfusion Medicine and Immunohaematology (SIMTI). Blood Transfus. 2009;7:132-50.
13. Poterjoy B, Josephson C. Platelets frozen plasma, and cryoprecipitate: What is the clinical evidence for their use in the neonatal intensive care unit? Semin Perinatol. 2009;33:66-74.
14. Chang TT. Transfusion therapy in critically ill children. Pediatrics and Neonatology. 2008;49:5-12.
15. Roback J, Cadwell S, Carson J, Devenport R. Evidence-based practice guidelines for plasma transfusion. Transfusion. 2010;50:1227-39.
16. Goldemberg N. Pediatric hemostasis and use of plasma components. Best Pract Res Clin Haematol. 2006;19:143-55.
17. Sorensen B, Bevan D. A critical evaluation of cryoprecipitate for replacement of fibrinogen. Br J Haematol. 2010;149:834-43.
18. Callun J, Karkouti K, Lin Y. Cryoprecipitate: The current state of knowledge. Transfus Med Rev. 2009;23: 177-88.
19. Rossaint R, Bouillon B, Cerny V, Coats T. Management of bleeding following major trauma an updated European guideline. Critical Care. 2010;14:R52.
20. Dressler A, Finck C, Carrol C, Bonnani C, Spinella P. Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a child. J Pediatr Surg. 2010;45:1530-3.
21. Dehmer J, Adamson W. Massive transfusion and blood product use in the pediatric trauma patient. Semin Pediatr Surg. 2010;19:286-91.
22. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010;137:209-20.
23. Sihler K, Napolitano L. Massive transfusion new insights. Chest. 2009;136:1654-67.
24. Downes K, Sarode R. Massive blood loss transfusion. Indian J Pediatr. 2001;68:145-9.
25. Barcelona S, Cote CH, Thompson A. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part I: hematologic and physiologic differences from adults; metabolic and infectious risks. Paediatr Anaesth. 2005;15:716-26.
26. Schouten E, van de Pol A, Turnel M, Jansen N. The effect of aprotinin, tranexamic acid, and aminocaproic acid blood loss and use of blood products in major pediatric surgery: A meta-analysis. Pediatr Crit Care Med. 2009;10:182-90.
27. Goobie S, Meier P, Pereira L, McGowan F, Prescilla R, Scharp L, et al. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011;114:862-71.
28. Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, et al. Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology. 2011;114:856-61.
29. Tzortzopolou A, Cepeda MS, Schuman R, Carr DB. Antifibrinolitic agents for reducing blood loss in scoliosis surgery in children (review). The Cochrane database of systematic review. 2009;Issue 1.
30. Grant JA, Howard J, Luntley J, Harder J, Aleissa S, Parsons D. Perioperative blood transfusion requirements in pediatric scoliosis surgery: the efficacy of tranexamic acid. J Pediatr Orthop. 2009;29:300-4.
31. Franchini M. The use of desmopressin as a hemostatic agent: a concise review. Am J Hematol. 2007;82:731-5.
32. Benito H, Hernandez R, Fernandez Reyes J. Management of perioperative bleeding in renal patients. Nefrologia. 2008;28:593-6.
33. Levy J, Kenishi A, Tanaka K. Prohemostatic agents to prevent perioperative blood loss. Semin Thromb Hemost. 2008;34:439-44.
34. Ozgonenel B, Rajpurkar M, Lussher J. How do you treat bleeding disorders with desmopressin? Postgrad Med J. 2007;83:159-63.
35. Franchini M, Lippi G. Recombinant activated factor VII: Mechanisms of action and current indications. Semin Thromb Hemost. 2010;36.
36. Logan A, Lawrence T, Goodnough T. Recombinant factor VIIa: An assessment of evidence regarding its efficacy and safety in the off-label setting. Hematology. 2010:153-9.
37. Persson E, Bolt G, Steentrup T, Ezban M. Recombinant coagulation factor VIIa - from molecular to clinical aspects of a versatile haemostatic agent. Thromb Res. 2010;125: 483-9.
38. Vincent J, Rossaint R, Riou B, Ozier Y, Zideman D. Recommendations on the use of recombinant a potential l universal hemostatic agent. Expert Opin Biol Ther. 2009;9:1325-33.
39. Alten J, Benner K, Green K, Toole B, Tofil N. Pediatric off label use of recombinant factor VIIa. Pediatrics. 2009;123:1066-72.
40. Hong I, Stachnik J. Unlabeled uses of factor VIIa (recombinant) in pediatric patients. Am J Health Syst Pharm. 2010;67:1909-19.
41. Witmer CM, Huang YS, Lynch K, Raffini LJ, Shah S. Off-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study. J Pediatr. 2011;158:820-5.
42. Levi M, Levy J, Friis H. Safety of recombinant activated factor VII in randomized clinical trials. N England J Med. 2010;363:19.
43. Lin Y, Stanworth S, Birchall J, Doree C. Use of recombinant factor VIIa for the prevention and treatment of bleeding in patients without hemophilia: a systematic review and meta-analysis. CMAJ. 2011;183:E9-19.
44. Fenger-Eriksen C, Ingersley J, Sorensen B. Fibrinogen concentrate - a potential universal hemostatic agent. Expert Opin Biol Ther. 2009;9:1325-33.
45. Franchinni M, Lippi G. Prothrombin complex concentrates: an update. Blood Transfus. 2010;8:149-54.
46. Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the use of antithrombin concentrates and prothrombin complex concentrates. Blood Transfus. 2009;7:325-34.
47. Perry D, Fitzmaurice D, Kitchen S, Mackie I. Point-of-care testing in haemostasis. Br J Haematol. 2010;150:501-14.
48. Sibylle A, Kozek-Langenecker. Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol. 2010;24:27-40.
49. Ganter M, Hofer C. Coagulation monitoring: Current techniques and clinical use of viscoelastic point of care coagulation devices. Anesth Analg. 2008;106:1366-75.
50. Lavoie J. Blood transfusion risks and alternative strategies in pediatric patients. Pediatric Anesthesia. 2011;21:14-24.
51. Verma S, Eisses M, Richards M. Blood conservation strategies in pediatric patient. Anesthesiol Clin. 2009;27:337-55.
52. Griffee M, DeLoughery T, Thorborg T. Coagulation management in massive bleeding. Current Opinion in Anaesthesiology. 2010;23:263-8.
How to Cite
1.
Zuluaga Giraldo M. Management of perioperative bleeding in children. Step by step review. Colomb. J. Anesthesiol. [Internet]. 2013 Jan. 1 [cited 2024 May 5];41(1):50-6. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/637
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2013-01-01
How to Cite
1.
Zuluaga Giraldo M. Management of perioperative bleeding in children. Step by step review. Colomb. J. Anesthesiol. [Internet]. 2013 Jan. 1 [cited 2024 May 5];41(1):50-6. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/637
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Narrative review
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