Utility of biomarkers in traumatic brain injury: a narrative review

  • Daniel A. Mendoza School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Karen D. López School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Raúl A. Echeverri a. School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia. b. Neurosciences and Neurosurgery, School of Medicine, Institute of Neurosciences, Universidad El Bosque, Research Team Leader INUB-MEDITECH, Universidad El Bosque, Fundación MEDITECH, Bogotá, Colombia
  • Laura Pastor Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
  • Steven Rueda School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Laura L. Fernández School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Daniela S. Mantilla School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • María F. Díaz School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • María C. Ramírez School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Diana C. Barragán School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia
  • Andrés M. Rubiano a. School of Medicine, Universidad El Bosque, Neurotrauma Research Seedbed, INUB-MEDITECH Research Team, Institute of Neurosciences, Universidad El Bosque, Bogotá, Colombia. b. Neurosciences and Neurosurgery, School of Medicine, Institute of Neurosciences, Universidad El Bosque, Research Team Leader INUB-MEDITECH, Universidad El Bosque, Fundación MEDITECH, Bogotá, Colombia

Abstract

Introduction: With the evolution of diagnostic techniques in traumatic brain injury (TBI), the study of neurological injury has made progress based on the concepts of primary and secondary injury, leading to the era of proteomics to understand the complex molecular events involved in the process.

Objectives: This narrative review is intended to discuss the state of the art of the most frequently used biomarkers in TBI, their clinical utility, and the implications for therapeutic decisionmaking protocols.

Materials and methods: In order to fulfill the objective of this paper, a literature review was conducted of the most important databases.

Results: Several biomarkers have been studied as prognostic factors in patients with TBI. Learning about their sensitivity and specificity in neurological injury, and its post-trauma evolution over time, has been the goal of various papers in the past few years.

Conclusion: Breakthroughs in the study of protein degradation make it necessary to broaden the spectrumand knowledge of new diagnostic methods in TBI. Further studies are needed to define the role of biomarkers and to promote protocols integrating specific values.

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How to Cite
1.
Mendoza DA, López KD, Echeverri RA, Pastor L, Rueda S, Fernández LL, Mantilla DS, Díaz MF, Ramírez MC, Barragán DC, Rubiano AM. Utility of biomarkers in traumatic brain injury: a narrative review. Colomb. j. anesthesiol. [Internet]. 2020Jul.1 [cited 2020Sep.25];48(3):155-61. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/912

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Published
2020-07-01
How to Cite
1.
Mendoza DA, López KD, Echeverri RA, Pastor L, Rueda S, Fernández LL, Mantilla DS, Díaz MF, Ramírez MC, Barragán DC, Rubiano AM. Utility of biomarkers in traumatic brain injury: a narrative review. Colomb. j. anesthesiol. [Internet]. 2020Jul.1 [cited 2020Sep.25];48(3):155-61. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/912
Section
Narrative review