Identification of a thromboelastographic pattern in children undergoing cardiac surgery with prolonged exposure to cardiopulmonary bypass☆

  • Orlando J. Tamariz-Cruz Cardiovascular Anaesthesia, Cardiovascular Surgery Division, Instituto Nacional de Pediatría, KARDIAS/CMABC, Mexico City, Mexico
  • Silvia Cruz-Sánchez Paediatric Anaesthesia, Surgery Department, Instituto Nacional de Pediatría, Mexico City, Mexico
  • Carolina Pérez-Pradilla Anaesthesia Department, Instituto Roosevelt de Ortopedia Infantil, Bogotá D.C., Colombia
  • Luis G. Motta-Amézquita Cardiovascular Anaesthesia, Cardiovascular Surgery Division, Instituto Nacional de Pediatría, KARDIAS/CMABC, Mexico City, Mexico
  • Hector Díliz-Nava Cardiovascular Surgery Division, Instituto Nacional de Pediatría, KARDIAS/CMABC, Mexico City, Mexico
  • Alexis Palacios-Macedo-Quenot Cardiovascular Surgery Division, Instituto Nacional de Pediatría, KARDIAS/CMABC, Mexico City, Mexico
Keywords: Thrombelastography, Thoracic surgery, Hemorrhage, Child, Blood Coagulation

Abstract

Background: Point-of-care thromboelastography is used for guiding peri-operative haemostatic therapy.

Objective: To identify a thromboelastographic pattern in children with prolonged cardiopulmonary bypass exposure.

Material and methods: A cohort study of 62 patients undergoing prolonged cardiopulmonary bypass was performed. Patients with preexisting coagulopathy, use of drugs known to interfere with clotting, hematocrit > 60%, weight < 3 kg, or hepatic disease were excluded. The thromboelastography study was conducted at the point of care.

Results: Baseline and rewarming reaction time values were 8.24 ± 6.35 and 7.66 ± 2.15min, respectively (p = 0.102). Baseline and rewarming angle values were 64.88 ± 13.08 and 54.67 ± 8.98 degrees, respectively (p < 0.001). Baseline and rewarming maximum amplitude values were 64.54 ± 12.31 and 43.14 ± 12.47 mm, respectively (p = 0.001). The same trend was observed when the cohort was divided into patients under and over 3 years of age, and patients under and over 10 kg of body weight.

Discussion: This study suggests the existence of a thromboelastographic pattern independent of age or weight in patients undergoing paediatric cardiac surgery with prolonged cardiopulmonary bypass exposure, characterised by a reduction of angle and maximum amplitude values, with no change in reaction time.

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How to Cite
1.
Tamariz-Cruz OJ, Cruz-Sánchez S, Pérez-Pradilla C, Motta-Amézquita LG, Díliz-Nava H, Palacios-Macedo-Quenot A. Identification of a thromboelastographic pattern in children undergoing cardiac surgery with prolonged exposure to cardiopulmonary bypass☆. Colomb. J. Anesthesiol. [Internet]. 2017Apr.1 [cited 2021Jan.26];45(2):108–113. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/255

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Published
2017-04-01
How to Cite
1.
Tamariz-Cruz OJ, Cruz-Sánchez S, Pérez-Pradilla C, Motta-Amézquita LG, Díliz-Nava H, Palacios-Macedo-Quenot A. Identification of a thromboelastographic pattern in children undergoing cardiac surgery with prolonged exposure to cardiopulmonary bypass☆. Colomb. J. Anesthesiol. [Internet]. 2017Apr.1 [cited 2021Jan.26];45(2):108–113. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/255
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