Anesthesia for intrauterine myelomeningocele correction: first successful experience in Peru. Case report

  • Marjorie Lisseth Calderón-Lozano Department of Anaesthesiology, Analgesia and Resuscitation, Instituto Nacional Materno Perinatal, Lima, Peru.
  • Pedro Saldaña-Montes Department of Anaesthesiology, Analgesia and Resuscitation, Instituto Nacional Materno Perinatal, Lima, Peru.
  • Renato Moreno-Gonzales Department of Anaesthesiology, Analgesia and Resuscitation, Instituto Nacional Materno Perinatal, Lima, Peru.
  • Walter R. Ventura-Laveriano Instituto Nacional Materno Perinatal, Lima, Peru.
Keywords: Relaxation, Anesthesia, Meningomyelocele, Case Reports, Peru

Abstract

Introduction:

In pregnancies with a diagnosis of fetal myelomeningocele (MMC), studies have shown that prenatal correction, as compared with postnatal correction, results in better outcomes in infancy, requiring less ventriculoperitoneal shunts, and resulting in improved motor function of the lower limbs. However, maternal morbidity, the risk of uterine repair dehiscence, uterine rupture secondary to hysterotomy, and the need for cesarean section are all increased. This case report is the first successful experience of intrauterine repair of a MMC in Peru.

Case presentation:

We describe the case of a primigravida at 25 weeks of gestation with a diagnosis of fetal malformation (MMC and Arnold Chiari II syndrome) taken to intrauterine correction of the neural tube defect under general anesthesia plus epidural analgesia.

Conclusion:

The use of total intravenous anesthesia associated with nitroglycerine infusion for uterine relaxation, ethylephrine infusion to maintain maternal hemodynamic stability, and adequate postoperative pain management with epidural analgesia was successful in this case.

References

1. Phillips LA, Burton JM, Evans SH. Spina bifida management. Curr Probl Pediatr Adolesc Health Care 2017;47:173-177.

2. Miller RS, Kuller JA. ACOG Committee opinion: maternal-fetal surgery for myelomeningocele. Obstet Gynecol 2017;130:e164-e167.

3. Carreras E, Maroto A, Arevalo S, et al. Prenatal treatment of myelomeningocele. Diagnprenat 2012;23:148-153.

4. Heuer GG, Moldenhauer JS, Adzick NS. Prenatal surgery for myelomeningocele: review of the literature and future directions. Childs Nerv Syst 2017;33:1149-1155.

5. Kabagambe SK, Chen YJ, Vanover MA, et al. New directions in fetal surgery for myelomeningocele. Childs Nerv Syst 2017;33:1185-1190.

6. Adzick S, Thorn E, Spong C. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 2011;364:993-1004.

7. Tarqui CB, Sanabria HA, Lam NM, et al. Incidence of neural tube defects in the National Maternal Perinatal Institute of Lima. Rev Chil Salud Publica 2009;13:82-89.

8. Sanabria HA, Tarqui CB, Arias J, et al. Impact of fortifying wheat flour with folic acid on neural tube defects in Lima, Peru. An Fac Med 2013;74:175-180.

9. Ferschl M, Ball R, Lee H, et al. Anesthesia for in utero repair of myelomeningocele. Anesthesiology 2013;118:1211-1223.

10. Kafali H, Kaya T, Gürsoy S, et al. The role of K(+) channels on the inhibitor effect of sevoflurane in pregnant rat myometrium. Anesth Analg 2002;94:174-178.

11. Okutomi T, Saito M, Kuczkowski KM. The use of potent inhalation agents for the ex-utero intrapartum treatment (exit) procedures: what concentrations? Acta Anesthesiol Belg 2007;58:97-99.

12. Zheng SQ, An LX, Cheng X, et al. Sevoflurane causes neuronal apoptosis and adaptability changes of neonatal rats. Acta Anaesthesiol Scand 2013;57:1167-1174.

13. Chatterjee D, Wood CL, Howley LW, et al. Use of intravenous anesthetics minimizes fetal cardiac dysfunction during prenatal myelomeningocele repair. Am J Obstet Gynecol 2016;214:103.

14. Saroa R, Sachan S, Palta S, et al. Obstetric use of nitroglycerin: anesthetic implications. Saudi J Anaesth 2013;7:350-352.

15. Belzarena SD. Ephedrine and etilefrine as vasopressor to correct maternal arterial hypotension during elective cesarean section under spinal anesthesia. Rev Bras Anestesiol 2006;56:223-229.

16. Bolaños D, Fonseca NJ, Socha NI, et al. Etilefrine vs. phenylephrine for hypotension during spinal anesthesia for cesarean section: multicenter, randomized, double blind controlled clinical trial. Rev Colomb Anestesiol 2016;44:89-96.

17. Devoto JC, Alcalde JL, Otayza F, et al. Anesthesia for myelomeningocele surgery in fetus. Childs Nerv Syst 2017;33:1169-1175.
How to Cite
1.
Calderón-Lozano ML, Saldaña-Montes P, Moreno-Gonzales R, Ventura-Laveriano WR. Anesthesia for intrauterine myelomeningocele correction: first successful experience in Peru. Case report. Colomb. J. Anesthesiol. [Internet]. 2018 Oct. 1 [cited 2024 Apr. 24];46(4):336-40. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/417

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Published
2018-10-01
How to Cite
1.
Calderón-Lozano ML, Saldaña-Montes P, Moreno-Gonzales R, Ventura-Laveriano WR. Anesthesia for intrauterine myelomeningocele correction: first successful experience in Peru. Case report. Colomb. J. Anesthesiol. [Internet]. 2018 Oct. 1 [cited 2024 Apr. 24];46(4):336-40. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/417
Section
Case Report / Case Series

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