Correlation and agreement between arterial and central venous blood pH, P02) PC02 and HC03- values of mechanically ventilated patients in intensive care unit: A prospective observational study

  • Mohd Sabihul Islam Department of Anaesthesiology, JN Medical College, AMU, Aligarh, India
  • S. Moied Ahmed FICCM, FCCP, FIMSA, Department of Anaesthesiology, JN Medical College, AMU, Aligarh, India
  • S. Bano Intensive Care Unit, Department of Anaesthesiology, JN Medical College, AMU, Aligarh, India
  • Abu Nadeem Intensive Care Unit, Department of Anaesthesiology, JN Medical College, AMU, Aligarh, India
  • Mozammil Shafi Intensive Care Unit, Department of Anaesthesiology, JN Medical College, AMU, Aligarh, India
Keywords: Respiration artificial, Intensive care, Homeostasis, Acid-base equilibrium, Blood gas analysis

Abstract

Background: The procedure for arterial blood sampling can be technically difficult with limitations and complications.

Aims: To evaluate the correlation and agreement between arterial and central venous blood pH, PO2, PCO2 and HCO3- values and infer whether central venous blood gas (CVBG) values could replace arterial blood gas (ABG) values. Design: Prospective observational study.

Methods and Material: A total of 100 samples were collected from 50 adult normotensive and normothermic patients requiring mechanical ventilation. Arterial blood was collected from radial artery and within 2 minutes central venous blood was withdrawn from the same patient. Correlation and agreement was tested using Pearson's Correlation and Bland Altman Analysis.

Results: The pH, PO2, PCO2 and HCO3- of CVBG correlated significantly with arterial values (rpH = 0.88, < 0.001; rpo2 = 0.358, <0.05; rpco2 = 0.470, < 0.001 and Thco3 =0.714, < 0.001). Regression equations were derived to predict AVG values from CVBG values as follows: Arterial pH = 0.879 x central venous pH + 0.9422 (constant), arterial PO2 = 0.421 x central venous PO2 +114.4 (constant), R2 = 0.128, arterial PCO2 = 0.429 x central venous PCO2 + 24.627 (constant), R2 = 0.2205 and arterial HCO3 = 1.045 x central venous HCO3 + 3.402 (constant), R2 = 0.5101.The mean arterial minus venous difference forpH, PO2, PCO2, and bicarbonate was 0.053 ±0.014, 56.04 ±15.74, 2.20 ± 4.4 and 4.30 ±1.64 respectively. Bland-Altman plots for agreement of pH, PO2, PCO2, and bicarbonate showed 95% limits of agreement of -0.04 to 0.146, -52.51 to 164.59, -26.61 to 31.01 and -7.0 to 15.6, respectively.

Conclusions: The arterial pH, PO2, PCO2 and HCO3- values correlated well with central venous values. However, only the arterial pH value can replace the central venous pH value.

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How to Cite
1.
Sabihul Islam M, Ahmed SM, Bano S, Nadeem A, Shafi M. Correlation and agreement between arterial and central venous blood pH, P02) PC02 and HC03- values of mechanically ventilated patients in intensive care unit: A prospective observational study. Colomb. J. Anesthesiol. [Internet]. 2013 Jul. 1 [cited 2024 Apr. 18];41(3):190–195. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/691

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Published
2013-07-01
How to Cite
1.
Sabihul Islam M, Ahmed SM, Bano S, Nadeem A, Shafi M. Correlation and agreement between arterial and central venous blood pH, P02) PC02 and HC03- values of mechanically ventilated patients in intensive care unit: A prospective observational study. Colomb. J. Anesthesiol. [Internet]. 2013 Jul. 1 [cited 2024 Apr. 18];41(3):190–195. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/691
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