Transfusion in trauma

  • Víctor Hugo González Cárdenas a. Clinical Epidemiologist La Samaritana University Hospital, "Mandragora". b. Anesthesia Research Group, Anesthesiologist, San José Children's Hospital. c. Head of Anesthesia Research Deorum Opus-FUCS. d. Intensivist, University Clinic Colombia-Sanitas Internacional. e. Instructor of Anesesiology - FUCS, Clnical. f. Professor, Universidad de la Sabana, Graduate Program in Anesthesiology, Bogotá, Colombia
Keywords: Hemorrhage, Blood transfusion, Trauma, Recombinant FVIIa, Tranexamic acid, Coagulopathies


Massive transfusion is considered a key component in the acute management of massive hemorrhage. While the existing protocols do not standardize its use, they do recommend its timely administration and a dose adjusted to the type of blood product, a proportionate ratio between hemocomponents and appropriate adjuvant drug support, in addition to techniques that promote bleeding control and prevent syndromes that could trigger a fatal outcome. This non-systematic review is intended to summarize the current concepts on the acute management of massive bleeding in trauma, from a non-surgical perspective.

The search was limited to the articles of the last 10 years and included primary and secondary data basis, leading to a snowball technique.


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48. Spinella PC, Perkins JG, McLaughlin DF, Niles SE, Grathwohl KW, Beekley AC, et al. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma. 2008;64:286-94.

49. Harrison TD, Laskosky J, Jazaeri O, Pasquale MD, Cipolle M. Low-dose recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage. J Trauma. 2005;59:150-4.

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52. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al., CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet. 2010;376: 23-32.

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How to Cite
González Cárdenas VH. Transfusion in trauma. Colomb. J. Anesthesiol. [Internet]. 2012Oct.1 [cited 2021Jan.26];40(4):287–292. Available from:


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How to Cite
González Cárdenas VH. Transfusion in trauma. Colomb. J. Anesthesiol. [Internet]. 2012Oct.1 [cited 2021Jan.26];40(4):287–292. Available from:
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