The basic principies of anesthesia for the neonate

  • Lynn D. Martin Departments of Anesthesiology & Pain Medicine and Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA
Keywords: Infant newborn, Anesthesia general, Pharmacology, Anesthesia conduction, Pharmacokinetics


Introduction: There are significant developmental differences in physiology and pharmacology in neonates that make the conduct of a safe anesthetic much more challenging in a neonate.

Objectives: Complete a focused review of the current knowledge of the physiological and pharmacologic differences seen in newborns that impact the safe administration of anesthesia.

Methods: A selective review of literature in developmental changes in physiology and pharmacology was completed.

Results: This knowledge acquired in the review was used to establish common principles for the safe administration of anesthesia to newborn patients.

Conclusion: In spite of the persistence of large gaps in our knowledge in this physiology and pharmacology, common modern anesthetic management principles for neonatal surgery have significantly improved clinical outcomes.


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How to Cite
Martin LD. The basic principies of anesthesia for the neonate. Colomb. J. Anesthesiol. [Internet]. 2017 Jan. 1 [cited 2024 Apr. 23];45(1):54-61. Available from:


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How to Cite
Martin LD. The basic principies of anesthesia for the neonate. Colomb. J. Anesthesiol. [Internet]. 2017 Jan. 1 [cited 2024 Apr. 23];45(1):54-61. Available from:
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