Developmental pharmacokinetics and pharmacodynamics of parenteral opioids and nonsteroidal anti-nflammatory drugs in neonates and infants

  • Lizabeth Martin Seattle Children's Hospital, University of Washington, Department of Anesthesiology and Pain Medicine, Seattle, USA
  • Nathalia Jiménez Seattle Children's Hospital, University of Washington, Department of Anesthesiology and Pain Medicine, Seattle, USA
  • Anne M. Lynn Seattle Children's Hospital, University of Washington, Department of Anesthesiology and Pain Medicine, Seattle, USA
Keywords: Infant, Infant care, Analgesics, Opioid, Pharmacokinetics, Pharmacology

Abstract

Introduction: Pharmacology of infants is understudied and different from other populations.

Objective: To review the unique features of neonatal and infant physiology that impact drug handling and the pharmacokinetics of analgesics, including opioids, ketorolac and acetaminophen.

Materials and methods: This article is a narrative review of the literature from the authors' point of view that constitutes a summary of the information presented at the annual Colombian Society for Anesthesia meeting in Cali, Colombia June 2015.

Conclusions: Pharmacology in neonates and infants is unique and must be considered in this vulnerable population. Recommendations for administration of these analgesics are presented based on their unique pharmacokinetic properties. Individual patient variation and clinical response must also be taken into account.

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How to Cite
1.
Martin L, Jiménez N, Lynn AM. Developmental pharmacokinetics and pharmacodynamics of parenteral opioids and nonsteroidal anti-nflammatory drugs in neonates and infants. Colomb. J. Anesthesiol. [Internet]. 2017 Jan. 1 [cited 2024 Feb. 28];45(1):72-9. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/51

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Published
2017-01-01
How to Cite
1.
Martin L, Jiménez N, Lynn AM. Developmental pharmacokinetics and pharmacodynamics of parenteral opioids and nonsteroidal anti-nflammatory drugs in neonates and infants. Colomb. J. Anesthesiol. [Internet]. 2017 Jan. 1 [cited 2024 Feb. 28];45(1):72-9. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/51
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