From pharmacokinetics to pharmacodynamics -Are we ready for 3D software?
Keywords:
Anesthesia, Balanced anesthesia, Pharmacology, Pharmacokinetics, Software, Intravenous
Abstract
The relationship between the dose and plasma concentration of a drug is determined by pharmacokinetics. However, difficulties arise when more than one drug is administered simultaneously. There is currently a gap in the teaching model when trying to convey the significance of pharmacodynamic interactions. In this article the authors reflect on the importance of developing a software that simplifies the pharmacokinetic concepts of two drugs, turning them into one single variable in space as a function of time. Together with depth of anesthesia monitoring and the pain control variables, this model will bring pharmacokinetics and pharmacodynamics together and provide a teaching tool for improved understanding of these concepts.
References
1. Gambús PL, Trocóniz IS. Pharmacokinetic-pharmacodynamic modelling in anaesthesia. Br J Clin Pharmacol. 2015;79:72-84.
2. Billard V. Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs: from modeling to clinical use. Faculty Rev. 2015;4:F1000-289.
3. Bocanegra JC, Botero LF, Tafur LA. Anestesia Balanceada. Bogotá: Sociedad Colombiana de Anestesiología y Reanimación, Bogotá; 2015.
4. Tafur LA, Lema E. Anestesia total intravenosa: d la farmacéutica ala farmacocinética [Total intravenous anesthesia: from pharmaceutics to pharmacokinetics]. Rev Colomb Anestesiol. 2010;38:215-31.
5. Hendrickx JFA, Eger EI, Sonner JM, Shafer SL. Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008;107:494-506.
6. GE Healthcare. Anesthesia Navigator Applications Suite; 2017 [Cited 14 Jul 2017]. Available from: https://goo.gl/wwHGyy
7. Dräger SmartPilot(r) View. Dräger: Tecnología para toda la vida; 2017 [Cited 14 Jul 2017]. Available from: https://goo.gl/ggiZsU.
8. Cirillo V, Zito Marinosci G, de Robertis E, Iacono C, Piazza O, Romano GM, et al. Navigator(r) and SmartPilot(r) view are helpful in guiding anesthesia and reducing anesthetic drug dosing. Minerva Anestesiol. 2015:1-22.
9. Mertens MJ, Olofsen E, Engbers FHM, Burm AGL, Bovill JG, Vuyk J. Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol interactions. Anesthesiology. 2003;99:347-59.
10. Minto CF, Schnider TW, Short TG, Gregg KM, Gentilini A, Shafer SL. Response surface model for anesthetic drug interactions. Anesthesiology. 2000;92:1603-16.
11. Vuyk J. Clinical interpretation of pharmacokinetic and pharmacodynamic propofol-opioid interactions. Acta Anaesthesiol Belg. 2001;52:445-51.
12. Nieuwenhuijs DJF, Olofsen E, Romberg RR, Sarton E, Ward D, Engbers F, et al. Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index. Anesthesiology. 2003;98: 312-22.
13. Bouillon T, Bruhn J, Radu-Radulescu L, Bertaccini E, Park S, Shafer S. Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. Anesthesiology. 2002;97:1350-62.
2. Billard V. Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs: from modeling to clinical use. Faculty Rev. 2015;4:F1000-289.
3. Bocanegra JC, Botero LF, Tafur LA. Anestesia Balanceada. Bogotá: Sociedad Colombiana de Anestesiología y Reanimación, Bogotá; 2015.
4. Tafur LA, Lema E. Anestesia total intravenosa: d la farmacéutica ala farmacocinética [Total intravenous anesthesia: from pharmaceutics to pharmacokinetics]. Rev Colomb Anestesiol. 2010;38:215-31.
5. Hendrickx JFA, Eger EI, Sonner JM, Shafer SL. Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008;107:494-506.
6. GE Healthcare. Anesthesia Navigator Applications Suite; 2017 [Cited 14 Jul 2017]. Available from: https://goo.gl/wwHGyy
7. Dräger SmartPilot(r) View. Dräger: Tecnología para toda la vida; 2017 [Cited 14 Jul 2017]. Available from: https://goo.gl/ggiZsU.
8. Cirillo V, Zito Marinosci G, de Robertis E, Iacono C, Piazza O, Romano GM, et al. Navigator(r) and SmartPilot(r) view are helpful in guiding anesthesia and reducing anesthetic drug dosing. Minerva Anestesiol. 2015:1-22.
9. Mertens MJ, Olofsen E, Engbers FHM, Burm AGL, Bovill JG, Vuyk J. Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol interactions. Anesthesiology. 2003;99:347-59.
10. Minto CF, Schnider TW, Short TG, Gregg KM, Gentilini A, Shafer SL. Response surface model for anesthetic drug interactions. Anesthesiology. 2000;92:1603-16.
11. Vuyk J. Clinical interpretation of pharmacokinetic and pharmacodynamic propofol-opioid interactions. Acta Anaesthesiol Belg. 2001;52:445-51.
12. Nieuwenhuijs DJF, Olofsen E, Romberg RR, Sarton E, Ward D, Engbers F, et al. Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index. Anesthesiology. 2003;98: 312-22.
13. Bouillon T, Bruhn J, Radu-Radulescu L, Bertaccini E, Park S, Shafer S. Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. Anesthesiology. 2002;97:1350-62.
How to Cite
1.
Tafur-Betancourt LA, Lema FE, Del Mar-Milla GM, Londoño A, Navarro-Vargas JR. From pharmacokinetics to pharmacodynamics -Are we ready for 3D software?. Colomb. J. Anesthesiol. [Internet]. 2017 Oct. 1 [cited 2024 Apr. 18];45(4):335–339. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/562
Downloads
Download data is not yet available.
Published
2017-10-01
How to Cite
1.
Tafur-Betancourt LA, Lema FE, Del Mar-Milla GM, Londoño A, Navarro-Vargas JR. From pharmacokinetics to pharmacodynamics -Are we ready for 3D software?. Colomb. J. Anesthesiol. [Internet]. 2017 Oct. 1 [cited 2024 Apr. 18];45(4):335–339. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/562
Issue
Section
Essay
Altmetric
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
