Manual vs. target-controlled infusion induction with propofol: An observational study

  • Lourdes Ferreira Laso Department of Anaesthesiology, Reanimation and Pain Management, San Peter Hospital, Logroño, Spain
  • Amanda López-Picado Araba Research Unit, Araba University Hospital, Vitoria, Spain
  • Erika Olea de La Fuente Department of Anaesthesiology, Reanimation and Pain Management, Araba University Hospital, Vitoria, Spain
  • Ana Mendiguren Murua Department of Anaesthesiology, Reanimation and Pain Management, Araba University Hospital, Vitoria, Spain
  • Clara Sánchez-Castro Department of Anaesthesiology, Reanimation and Pain Management, Araba University Hospital, Vitoria, Spain
  • Lorena Pipaon Ruilope Department of Anaesthesiology, Reanimation and Pain Management, Araba University Hospital, Vitoria, Spain
  • César Valero-Martínez Department of Anaesthesiology, Reanimation and Pain Management, Araba University Hospital, Vitoria, Spain
Keywords: Propofol, Anesthesia, Observational study, Anesthesia recovery period, Infusion pumps

Abstract

Background: Target-controlled infusion (TCI) systems allow the administration of drug to achieve a target blood or site-effect concentration. We determine induction and recovery times and the amount of drug used with TCI systems vs. manual induction. Objective: To determine whether the induction of propofol TCI and manual infusion are two comparable techniques.

Methods: A retrospective observational study was conducted in which sixty-two ASA I-II patients scheduled for elective surgery received induction using TCI or manually. Anaesthetic induction was achieved with remifentanil (0.25 μg/kg/min) and propofol (manual bolus injection: 2 mg/kg, or target blood concentration: 5 μg/ml with the TCI system [Marsh model]) with maintenance doses of remifentanil (0.15 μg/kg/min) and propofol (manually 0.10 mg/kg/min or 2.5-4 μg/ml using the TCI system). In both groups, rocuronium bromide was used (induction and maintenance doses: 0.6 and 0.3 mg/kg, respectively) as was morphine (0.1 mg/kg) 45 min before the end of the surgery.

We measured: induction, operative and recovery mean times; bispectral index, heart rate, blood pressure, costs, haemodynamic instability, and intraoperative awareness. A telephone questionnaire was administered 1 month later.

Results: The mean induction time was longer in the TCI than the manual group (1.76 ± 0.94 vs. 0.9 ±0.4 min; < 0.001), but the total dose of propofol (TCI: 112.4 ±60.9 vs. manual: 133.8 ± 80.3 ml, = 0.241) tended to be smaller and the recovery time was significantly shorter (TCI: 7.48 ±3.1 vs. manual: 10.3 ± 4.9 min) (p = 0.008).

Condusions: Induction with propofol using TCI is similar to manually delivered propofol

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How to Cite
1.
Ferreira Laso L, López-Picado A, Olea de La Fuente E, Mendiguren Murua A, Sánchez-Castro C, Pipaon Ruilope L, Valero-Martínez C. Manual vs. target-controlled infusion induction with propofol: An observational study. Colomb. j. anesthesiol. [Internet]. 2016Oct.1 [cited 2020Sep.27];44(4):272–277. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/599

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Published
2016-10-01
How to Cite
1.
Ferreira Laso L, López-Picado A, Olea de La Fuente E, Mendiguren Murua A, Sánchez-Castro C, Pipaon Ruilope L, Valero-Martínez C. Manual vs. target-controlled infusion induction with propofol: An observational study. Colomb. j. anesthesiol. [Internet]. 2016Oct.1 [cited 2020Sep.27];44(4):272–277. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/599
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